Potential Drug Targets for Neuroregeneration and Repair

Abstract

Unlike the peripheral nervous system (PNS) the adult mammalian central nervous system (CNS) does not spontaneously regenerate after injury. Numerous axon-inhibitory molecules are present in the injured CNS and various strategies for overcoming these obstacles and enhancing CNS regeneration had been experimentally developed. Adult neuroregeneration is a complex process, beyond the common knowledge of neurogenesis that also comprises endogenous neuroprotection leading to neuroplasticity and neurorestoration, a therapeutical approach of implantation of viable cells. Regeneration in the CNS implies that new neuron generate either through proliferation of endogenous stem/progenitor cells or by administration of exogenous stem/precursor cells with potential to substitute for lost tissue, or can be maintained by targeting the axon inhibitory molecule in the CNS. Here, the main focus of review emphasis on the axon inhibitory molecules, which prevents neuroregeneration and repair;