Abstract
Two new rearranged linear angucycline glycosides, designated grincamycins G and H (1 and 2), together with three known congers P-1894B (vineomycin A 1, 3), saquayamycin B (4) and vineomycin B 2 (5), were obtained from marine-derived actinomycete Streptomyces lusitanus SCSIO LR32. The structures of 1 and 2 were elucidated by MS, 1D and 2D NMR techniques. Compounds 2-5 showed significant inhibitory effect on Jurkat T-cell proliferation with IC 50 values of 3.0, 0.011, 0.037 and 0.3 μM, respectively.
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CITATION STYLE
Zhu, X., Duan, Y., Cui, Z., Wang, Z., Li, Z., Zhang, Y., … Huang, H. (2017). Cytotoxic rearranged angucycline glycosides from deep sea-derived Streptomyces lusitanus SCSIO LR32. Journal of Antibiotics, 70(7), 819–822. https://doi.org/10.1038/ja.2017.17
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