Current issues in the design and interpretation of clinical trials

Abstract

Though there have been considerable improvements in the use of statistical methods for clinical trials in recent years, there remain major practical difficulties in the design and interpretation of many trials. This paper concentrates. on problems relating to randomisation, the overemphasis on significance testing, and the inadequate size of many trials. Each topic is illustrated by examples from recent trials. © 1985, British Medical Journal Publishing Group. All rights reserved.