Abstract
A new briarane-type diterpenoid, briaviolide Q (1), along with a known analogue, excavatolide Z (2), were obtained from a cultured octocoral Briareum violaceum. Details of the isolation and structure determination of briarane 1 from spectroscopic data are presented in this paper. In RAW264.7 cells, a macrophage-like murine cell line, briarane 1 was found to inhibit the protein expression of pro-inflammatory inducible nitric oxide synthase (iNOS) in cells stimulated by lipopolysaccharide (LPS).
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Tsai, T. C., Xu, J. H., Li, M. J., Chen, J. J., Su, J. H., Wu, Y. C., … Sung, P. J. (2018). Briaviolide Q, a new briarane from the cultured Briareum violaceum. Natural Product Communications, 13(10), 1235–1237. https://doi.org/10.1177/1934578x1801301001
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