The exon trapping assay partly discriminates against alternatively spliced exons

Abstract

A cosmld containing eight exons of the gene coding for the microtubule-associated tau protein was subjected to the exon trapping assay. All the constitutive exons contained in the cosmld (4, 5, 7 and 9) were efficiently captured regardless of size. Of the four alternatively spliced exons, three (3,4A and 8) were not isolated by the assay, but the behavior of exon 6 depended on the Identity of its flanking exons. © 1993 IRL Press at Oxford University Press.