Synthesis and DNA binding properties of alkyl-linked bis(benzimidazole) compounds.

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Abstract

We have synthesized novel alkyl-linked bis(benzimidazole) compounds and studied their DNA binding properties by spectroscopic (absorption, CD, flow dichroism and fluorescence) and viscosity measurements. The results indicate that bis(benzimidazole) compounds interact with DNA both by intercalation and by groove binding.

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Kubota, Y., Fujii, H., Liu, J., & Tani, S. (2001). Synthesis and DNA binding properties of alkyl-linked bis(benzimidazole) compounds. Nucleic Acids Research. Supplement (2001), (1), 101–102. https://doi.org/10.1093/nass/1.1.101

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