An Automated Synthesis-Purification-Sample-Management Platform for the Accelerated Generation of Pharmaceutical Candidates

Abstract

A flexible and integrated flow-chemistry-synthesis-purification compound-generation and sample-management platform has been developed to accelerate the production of small-molecule organic-compound drug candidates in pharmaceutical research. Central to the integrated system is a Mitsubishi robot, which hands off samples throughout the process to the next station, including synthesis and purification, sample dispensing for purity and quantification analysis, dry-down, and aliquot generation. © 2013 Society for Laboratory Automation and Screening.