Agouti-related peptide-expressing neurons are mandatory for feeding

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Abstract

Multiple hormones controlling energy homeostasis regulate the expression of neuropeptide Y (NPY) and agouti-related peptide (AgRP) in the arcuate nucleus of the hypothalamus. Nevertheless, inactivation of the genes encoding NPY and/or AgRP has no impact on food intake in mice. Here we demonstrate that induced selective ablation of AgRP-expressing neurons in adult mice results in acute reduction of feeding, demonstrating direct evidence for a critical role of these neurons in the regulation of energy homeostasis. © 2005 Nature Publishing Group.

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Gropp, E., Shanabrough, M., Borok, E., Xu, A. W., Janoschek, R., Buch, T., … Brüning, J. C. (2005). Agouti-related peptide-expressing neurons are mandatory for feeding. Nature Neuroscience, 8(10), 1289–1291. https://doi.org/10.1038/nn1548

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