Facile and rapid synthesis of polysubstituted imidazoles by employing Y(NO 3) 3×6H 2O as catalyst

Abstract

An efficient and environmentally adapted synthesis of polysubstituted imidazoles in one-pot and multicomponent reaction of various aldehydes, benzil, aliphatic and aromatic primary amines and ammonium acetate under solvent-free condition is reported. Highly efficient role of Y(NO 3) 3×6H 2O as catalyst in this synthesis was shown. By this advantage, several polysubstituted imidazoles as pharmaceutical important molecules can be prepared in high yield and high purity. This method is very easy and rapid for the synthesis of imidazole derivatives. All products were deduced from their IR and NMR spectroscopic and elemental analysis data. The catalyst exhibited remarkable reusable activity.