Estudo fitoquímico e avaliação da atividade larvicida de Pterodon polygalaeflorus Benth (Leguminosae) sobre Aedes aegypti

Abstract

Chemical investigation of the hexane and methanol extracts of the fruits of Pterodon polygalaefl orus (Leguminosae) resulted in the isolation and identifi cation of furanic diterpenes: 6-?-acetoxivouacapane, 6-?-hidroxyvouacapane and vouacapane, which is related by the fi rst time as a natural product. The structures of these compounds were established by spectroscopic analysis, including 2D NMR experiments. The 6- ?-acetoxivouacapane, the hexane and methanol extracts, and the essential oil were evaluated on 3rd instar larvae of Aedes aegypti and only the hexane extract showed good larvicidal activity with LC50 23.99 ? 0.75 ?g/mL.