Tratamiento con membrana de la cáscara de huevo para curación de heridas superficiales en ratones Membrana de cáscara de huevo para curación de heridas

Abstract

Introduction: Eggshell membranes offer beneficial properties for tissue regeneration and they are important for biomedical applications. Objective: Demonstrate the effectiveness of eggshell membranes in the treatment of superficial open wounds compared to the conventional procedure. Materials and methods: 15 mm linear wounds were made on the back of 10 male CF-1 mice. The mice were divided into four groups. One group did not receive any treatment and the other groups were exposed to a conventional treatment, eggshell membranes dressing and eggshell membranes powder. The evolution of the wounds were registered by photographs. Wound length and healing time were measured, and length reduction rate and percentage of healing were calculated. Percentage healing data were analyzed by ANOVA with post hoc Dunnett test (P<0.05). Results: Treatments with eggshell membranes and membrane powder presented a wound length reduction rate of 1.009 and 1.020 mm/day, greater than the conventional treatment of 0.852 mm/day, a healing time of 12 days less than 16-day conventional treatment. Statistical analysis showed a significance differences between eggshell membrane treatments and the conventional treatment. Conclusions: Eggshell membranes dressing, and eggshell membrane powder applied to open superficial wounds in mice were more effective than the conventional treatment in regenerating injured tissue.