Antipyretic potential of Swertia chirata Buch ham. Root extract

Abstract

The aqueous extract of Swertia chirata Buch Ham. Root (ASC) (Family: Gentianaceae) was evaluated for its antipyretic potential on Brewer's yeastinduced pyrexia in albino rats and Typhoid-Paratyphoid A, B vaccine induced Hyperexia in rabbits. In both models, the extract, at dose of 200 mg kg -1 body wt. and 400 mg kg -1 body weight, produced significant (p<0.001) reduction in elevated body temperature in a dose dependent manner. The antipyretic effect of the extract was comparable to that of paracetamol (150 mg kg -1 body weight, p.o.), a standard antipyretic agent. © Bhargava et al.; licensee Österreichische Apotheker-Verlagsgesellschaft m. b. H.