Abstract
A cyclic pseudo-peptide receptor for acetylcholine has been amplified and isolated from a dynamic combinatorial library by virtue of templated stabilization under thermodynamic control (see scheme, TFA = trifluoroacetic acid). This is a demonstration of significant molecular amplification in dynamic systems to evolve a novel receptor.
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Cousins, G. R. L., Furlan, R. L. E., Ng, Y. F., Redman, J. E., & Sanders, J. K. M. (2001). Identification and isolation of a receptor for N-methyl alkylammonium salts: Molecular amplification in a pseudo-peptide dynamic combinatorial library. Angewandte Chemie - International Edition, 40(2), 423–428. https://doi.org/10.1002/1521-3773(20010119)40:2<423::AID-ANIE423>3.3.CO;2-Y
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