Adrenal disease is an uncommon manifestation of hepatitis C infection and its related treatment regimen. This is a case of subclinical hypoadrenalism, probably induced by hepatitis C infection and further exacerbated by interferon-α2β and Ribavirin therapy. The adrenal deterioration during the treatment course was observed closely with 24-hour salivary profiles and 250 μg adrenocorticotropin stimulation tests using parallel serum and salivary cortisol concentrations. A number of possible pathogenic mechanisms are discussed, and the controversy over its management is emphasized.
CITATION STYLE
Tran, H. A., Song, S., Lojewski, R. J., & Reeves, G. E. (2008). Exacerbation of hepatitis C induced subclinical hypoadrenalism by Interferon-alpha2beta: A case report. Cases Journal, 1(1). https://doi.org/10.1186/1757-1626-1-157
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