Alkylation of α-Oxo-Compounds through C(sp3)-H Functionalization of 2-Methyl Quinolines Under Catalyst- and Solvent-Free Conditions

Abstract

Highly facile approach of chemoselective alkylation of α-oxo compounds such as α-keto amides, α-keto esters, isatins, and cyclic-α-diketones is developed through C(sp3)-H functionalization of 2-methyl quinolines under solvent and catalyst-free conditions. Further, we complemented the efficacy of this green synthetic protocol by demonstrating the broad substrate diversity, gram-scale synthesis, and new synthetic transformations of the obtained products.