Plasma, erythrocyte membrane bound enzymes and tissue histopathology in male Wistar rats exposed to common insecticides

Abstract

Low doses (one-fourth of the LD50) of dichlorvos (DDVP), lambda-cyhalothrin (LMB), cypermethrin (CPM), and imidacloprid (IMP) were administered to adult male Wistar rats for 3 weeks. Erythrocyte antioxidant enzymes, biomarkers of tissue toxicity and histopathology of some visceral organs, were assessed. Glucose-6-phosphate dehydrogenase (G6PD), glutathione-S-transferase (GST), acetylcholine (ACH), and body weight decreased significantly in DDVP- and LMB-treated rats only. However, glutathione (GSH) levels decreased significantly in rats treated with DDVP and IMP. Lipid peroxidation (LPO) increased significantly in plasma of DDVP and erythrocyte of DDVP, CPM, and IMP as compared to the control. Plasma urea and creatinine were insignificant, while aspartate aminotransferase (AST) and alanine amino transferase (ALT) increased significantly in DDVP only; these observations are consistent with the histopathology.