Characterization and evaluation of avermectin solid nanodispersion prepared by microprecipitation and lyophilisation techniques

5Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.

Abstract

Poorly water-soluble and photosensitive pesticide compounds are difficult to formulate as solvent-free nanoformulations with high efficacy. A avermectin solid nanodispersion with a mean particle size of 188 nm was developed by microprecipitation and lyophilisation techniques. The suspensibility and wetting time of the solid nanodispersion in water were 99.8% and 13 s, respectively, superior to those of conventional water dispersible granules and wettable powders. The anti-photolysis performance of the nanoformulation was twice that of the technical material, and the biological activity against diamondback moths was more than 1.5 times that of the conventional solid formulations while taking LC 50 as the evaluation index. Moreover, the formulation composition substantially decreased the surfactant content and avoided organic solvents. Microprecipitation combined with lyophilisation is an easy and promising method to construct solid nanoformulations for pesticides with poor water solubility and environmental sensitivity. The application of the highly effective solid nanodispersion in crop production will have a great potential in reducing chemical residues and environmental pollution.

Cite

CITATION STYLE

APA

Cui, B., Wang, C., Zhao, X., Yao, J., Zeng, Z., Wang, Y., … Cui, H. (2018). Characterization and evaluation of avermectin solid nanodispersion prepared by microprecipitation and lyophilisation techniques. PLoS ONE, 13(1). https://doi.org/10.1371/journal.pone.0191742

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free