Attenuation of CClinduced oxidative stress and hepatonephrotoxicity by Saudi Sidr honey in rats

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Abstract

The present study was undertaken to investigate the possible protective effect of Saudi Sidr honey (SSH) on carbon tetrachloride (CCl induced oxidative stress and liver and kidney damage in rat. Moreover, the antioxidant activity and the phenolic and flavonoidal contents were determined. The hepatorenal protective activity of the SSH was determined by assessing biochemical, hematological, and histological parameters. Serum transaminases, ALP, GGT, creatinine, bilirubin urea, uric acid, and MDA level in liver and kidney tissues were significantly elevated, and the antioxidant status of nonprotein sulfhydryls, albumin, and total protein levels in liver and kidney were declined significantly in CClalone treated animals. Pretreatment with SSH and silymarin prior to the administration of CClsignificantly prevented the increase of the serum levels of enzyme markers and reduced oxidative stress. SSH also exhibited a significant lipid-lowering effect and caused an HDL-C enhanced level in serum. The histopathological evaluation of the liver and kidney also revealed that honey protected incidence of both liver and kidney lesions. Moreover, SSH showed a strong antioxidant activity in DPPH and β-carotene-linoleic acid assays. SSH was found to contain phenolic compounds. Additionally, the SSH supplementation restored the hepatocytes viability against 2′,7′- dichlorofluorescein (DCF) toxicity in ex vivo test. © 2013 Mohammed Al-Yahya et al.

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Al-Yahya, M., Mothana, R., Al-Said, M., Al-Dosari, M., Al-Musayeib, N., Al-Sohaibani, M., … Rafatullah, S. (2013). Attenuation of CClinduced oxidative stress and hepatonephrotoxicity by Saudi Sidr honey in rats. Evidence-Based Complementary and Alternative Medicine, 2013. https://doi.org/10.1155/2013/569037

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