Recent Advances on the Catalytic Functionalization of Quinoxalin- 2(1H)-ones via C-H Bond Activation

Abstract

Quinoxalin-2(1H)-ones are very important N-heterocyclic moieties found in natural products and pharmaceuticals, and exhibit an amazingly wide spectrum of biological properties. Numerous efforts have been devoted to the development of efficient approaches for the C-H bond activation and functionalization of quinoxalin-2(1H)-ones in recent years, including alkylation, benzylation, acylation, arylation,amination, amidation, phosphonation, and fluoroalkylation. The recent advances in this area are summarized and their reaction mechanisms are discussed.