A comparison of methods to determine neuronal phase-response curves

Abstract

The phase-response curve (PRC) is an important tool to determine the excitability type of single neurons which reveals consequences for their synchronizing properties. We review five methods to compute the PRC from both model data and experimental data and compare the numerically obtained results from each method. The main difference between the methods lies in the reliability which is infl uenced by the fl uctuations in the spiking data and the number of spikes available for analysis. We discuss the significance of our results and provide guidelines to choose the best method based on the available data. © 2010 Torben-Nielsen, Uusisaari and Stiefel.