Comparison between 200mg QD and 100mg BID oral celecoxib in the treatment of knee or hip osteoarthritis

Abstract

This network meta-analysis aimed to investigate the effectiveness and safety of 100mg BID and 200mg QD oral celecoxib in the treatment of OA of the knee or hip. PubMed, Embase and Cochrane Library were searched through from inception to August 2014. Bayesian network meta-analysis was used to combine direct and indirect evidences on treatment effectiveness and safety. A total of 24 RCTs covering 11696 patients were included. For the comparison in between the two dosage regimens, 100mg BID oral celecoxib exhibited a greater probability to be the preferred one either in terms of pain intensity or function at the last follow-up time point. For total gastrointestinal (GI) adverse effects (AEs), both of the two dosage regimens demonstrated a higher incidence compared to the placebo group. Further analyses of GI AEs revealed that only 200mg QD was associated with a significantly higher risk of abdominal pain when compared with placebo. Furthermore, 100mg BID showed a significantly lower incidence of skin AEs when compared with 200mg QD and placebo. Maybe 100mg BID should be considered as the preferred dosage regimen in the treatment of knee or hip OA.