Silica-supported dichlorophosphate: A recoverable cyclodehydrant for the eco-friendly synthesis of 2,5-disubstituted 1,3,4-oxadiazoles under solvent-free and microwave irradiation conditions

Abstract

A series of symmetrical and unsymmetrical 2,5-disubstituted 1,3,4-oxadiazoles were efficiently synthesized from the cyclodehydration of diacylhydrazines by using silica-supported dichlorophosphate as a recoverable cyclodehydrant in solvent-free medium under microwave irradiation. This protocol has advantages of no corrosion, no environmental pollution, accelerated rate, high yield and simple work-up procedure. ©2008 Sociedade Brasileira de Química.