Drug-resistant tuberculosis and modern approaches towards its diagnosis

Abstract

The review of the literature has shown that tuberculosis as a socially conditioned disease remains a serious problem in Kazakhstan and worldwide in general, currently taking the first position among the infectious diseases causing mortality. One of the main reasons of poor effectiveness of treatment and heavy mortality caused by tuberculosis is prevalence of multiple resistance of tuberculosis mycobacteria to antituberculotics. Modern immunological and molecular genetic tuberculosis diagnostic methods, in comparison with the traditional methods, are more sensitive and specific and allow within a short time detecting the presence of tuberculosis mycobacteria in bio-substrates and their resistance to drugs, which reduces the time of abacillation among the patients, increases effectiveness of the treatment, prevents prevalence of drug-resistant strains of tuberculosis mycobacteria, should allow decreasing the tuberculosis infection rate in general and incidence of Multiple/Extensive Drug-Resistant tuberculosis in particular.