Predictive model of periimplantitis in patients with periodontal disease: Genetic, microbiological and clinical risk factors

Abstract

15888 Poster DisplayClinical Research – Peri‐Implant Biology Background Patients with a history of periodontal disease are believed to be at greater risk than other patients for peri‐implant disease. The polymorphisms of IL‐1, certain systemic diseases, microbiological and other local factors are analyzed in this risk group to evaluate the influence of each of them on the survival of periimplantitis. Aim/Hypothesis To describe the survival of periimplantitis in the selected group of patients and to obtain an explanatory model of the disease. Material and Methods A prospective study was designed in a convenience cohort to evaluate the survival of periimplantitis, the risk potential of different clinical parameters, bacteria and the genetic markers of IL1B (+3954) and IL1RN (intron 2) polymorphisms with periimplant disease in patients with a history of periodontal disease. A total of 104 patients were selected, 617 implants placed by the same operator with the same surface and chemical composition. A total of 13 clinical variables and 11 bacteria were included. The patient's DNA was obtained by extracting epithelial cells from the oral mucosa and analyzed by real‐time PCR. Data processing and statistical analysis was performed using IBM® SPSS® Statistics 25 and MedCalc® Statistical Software version 14.8.1 . Results Several multivariate analyses were performed using the Cox proportional risk model (Wald) to estimate the relative risk of periimplantitis. Previously, bivariate analyses, Kaplan‐Meier models and Logrank tests were obtained to determine the variables included in the models. Values of P < 0.05 were considered significant. The model that best defined the disease with an 87.5% sensitivity included the genotypes considered to be at risk, two bacteria and the consumption of SSRIs and the level of oral hygiene. Conclusion and Clinical Implications The genotypes studied considered to be at risk, the consumption of antidepressants and the level of oral hygiene are related to an increased risk of suffering periimplantitis in patients with periodontal disease.