Modified polyriboinosinic polyribocytidylic acid, an immunological adjuvant

Abstract

Stabilization of polyriboinosinic polyribocytidylic acid against enzymatic hydrolysis by addition of poly 1 lysine and carboxymethylcellulose (PICLC) resulted in a compound with marked adjuvanticity. The primary antibody response of rhesus monkeys to formalin inactivated Venezuelan equine encephalomyelitis virus vaccine was significantly potentiated if the vaccine was combined with PICLC prior to vaccination. The antibody response was maintained at a significantly higher level than controls for 2.5 months postvaccination and paralleled immunological responses reported for live, attenuated (TC 83) vaccine.