Journal Article

Mesoporous silica nanoparticles incorporated with Ir(III) complexes: From photophysics to photodynamic therapy

Photodiagnosis and Photodynamic Therapy (2022) 40
DOI: 10.1016/j.pdpdt.2022.103052
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Abstract

Organically modified mesoporous silica nanoparticles (MSNs) containing Ir complexes (Ir1, Ir2 and Ir3) were successfully synthesized. These Ir‐entrapped MCM41-COOH nanoparticles have shown relevant photophysical characteristics including high efficiency in the photoproduction and delivery of singlet oxygen (1O2), which is particularly promising for photodynamic therapy (PDT) applications. In vitro tests have evidenced that complex@MCM41-COOH are able to reduce cell proliferation after 10 min of blue‐light irradiation in Hep-G2 liver cancer cells.

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Estevão, B. M., Vilela, R. R. C., Geremias, I. P., Zanoni, K. P. S., de Camargo, A. S. S., & Zucolotto, V. (2022). Mesoporous silica nanoparticles incorporated with Ir(III) complexes: From photophysics to photodynamic therapy. Photodiagnosis and Photodynamic Therapy, 40. https://doi.org/10.1016/j.pdpdt.2022.103052

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