Synthesis and anti-breast cancer activities of alpha mangostin derivatives: A review

Abstract

Alpha mangostin is the main part of xanton in mangosteen pericarp and is the main candidates for use in breast cancer drugs. Several studies were carried out in vitro, in vivo, and in silico study which showed that alpha mangostin and its derivatives have activity as a cure for breast cancer. This review article provides information alpha mangostin and its derivatives regarding their activities as anti-breast cancer which focuses on synthesis work, molecular targets, modes of action, and structure-activity relations (SAR). The development of beneficial alpha mangostin as complementary or alternative medicine can provide new opportunities for drug discovery against the disease.