A preparative method for synthesis of 4,5,6-trichloropyrimidine

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Abstract

The preparative method for synthesis of 4,5,6-trichloropyrimidme (1) from dimethyl chloromalonate and formamidine acetate is reported. In a two-step process the desired compound was obtained in overall yield 64% for the reaction scale 5-10g.

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Ostrowski, S., Swat, J., & Ma̧kosza, M. (2000). A preparative method for synthesis of 4,5,6-trichloropyrimidine. Arkivoc, 2000(6 SPEC.ISS), 905–908. https://doi.org/10.3998/ark.5550190.0001.607

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