Evaluation of Gut Microbial Changes in Human and Murine Models in Response to Antibiotics

Abstract

Widespread usage of antibiotics disrupted the host bacterial mutualism in the human intestine. The antibiotic alterations can drive the functionality of the gut microbiota towards a state similar to those observed under various disease states in humans. The emergence of antibiotic-resistant bacteria further spurred the development of the antimicrobial crisis all over the world. Antibiotics have an essential role in treating various diseases. To understand the intricate relationship between antibiotics and human gut microbiota, the basic understanding of the microbial signature of gut dysbiosis in human patients and murine models in response to antibiotics treatment is very crucial. Therefore, we examined the effects of most commonly used antibiotics on human and murine gut microbiota, when administered alone or in a combination, under this article.