A rapid screen for molecules that form duplex to duplex crosslinks in DNA

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Abstract

We describe a gold nanoparticle based assay that can rapidly determine the crosslinking of DNA duplexes by ligands. Such compounds have potential in targeting highly compacted DNA such as that found in the nucleosome. © 2013 The Royal Society of Chemistry.

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Marín, M. J., Rackham, B. D., Round, A. N., Howell, L. A., Russell, D. A., & Searcey, M. (2013). A rapid screen for molecules that form duplex to duplex crosslinks in DNA. Chemical Communications, 49(80), 9113–9115. https://doi.org/10.1039/c3cc45600e

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