Is TRALI caused by HLA class II too?

Abstract

Donor leukocyte antibodies are most often implicated in transfusion-related acute lung injury (TRALI), including antibodies against class I and II human leukocyte antigens (HLA) and human neutrophil antigens (HNA). Mechanisms supporting a role for HLA class I and HNA antibodies have been described but not for HLA class II antibodies. In this issue of Blood, Sachs et al substantiate a possible mechanism involving activation of monocytes.