Intelligent classification and analysis of essential genes using quantitative methods

Abstract

Essential genes are considered to be the genes required to sustain life of different organisms. These genes encode proteins that maintain central metabolism, DNA replications, translation of genes, and basic cellular structure, and mediate the transport process within and out of the cell. The identification of essential genes is one of the essential problems in computational genomics. In this present study, to discriminate essential genes from other genes from a non-biologists perspective, the purine and pyrimidine distribution over the essential genes of four exemplary species, namely Homo sapiens, Arabidopsis thaliana, Drosophila melanogaster, and Danio rerio are thoroughly experimented using some quantitative methods. Moreover, the Indigent classification method has also been deployed for classification on the essential genes of the said species. Based on Shannon entropy, fractal dimension, Hurst exponent, and purine and pyrimidine bases distribution, 10 different clusters have been generated for the essential genes of the four species. Some proximity results are also reported herewith for the clusters of the essential genes.