Cardiometabolic disease and features of depression and bipolar disorder: Population-based, cross-sectional study

Abstract

Background: The relative contribution of demographic, lifestyle and medication factors to the association between affective disorders and cardiometabolic diseases is poorly understood. Aims: To assess the relationship between cardiometabolic disease and features of depresion and bipolar disorder within a large population sample. Method: Cross-sectional study of 145 991 UK Biobank participants: multivariate analyses of associations between features of depression or bipolar disorder and five cardiometabolic outcomes, adjusting for confounding factors. Results: There were significant associations between mood disorder features and 'any cardiovascular disease' (depression odds ratio (OR)= 1.15, 95% CI 1.12-1.19; bipolar OR =1.28, 95% CI 1.14-1.43) and with hypertension (depression OR =1.15, 95% CI 1.13-1.18; bipolar OR =1.26, 95% CI 1.12-1.42). Individuals with features of mood disorder taking psychotropic medication were significantly more likely than controls not on psychotropics to report myocardial infarction (depression OR= 1.47, 95% CI 1.24-1.73; bipolar OR= 2.23, 95% CI 1.53-3.57) and stroke (depression OR= 2.46, 95% CI 2.10-2.80; bipolar OR =2.31, 95% CI 1.39-3.85). Conclusions: Associations between features of depression or bipolar disorder and cardiovascular disease outcomes were statistically independent of demographic, lifestyle and medication confounders. Psychotropic medication may also be a risk factor for cardiometabolic disease in individuals without a clear history of mood disorder.