Time-varying functional connectivity as Wishart processes

Abstract

We investigate the utility of Wishart processes (WPs) for estimating time-varying functional connectivity (TVFC), which is a measure of changes in functional coupling as the correlation between brain region activity in functional magnetic resonance imaging (fMRI). The WP is a stochastic process on covariance matrices that can model dynamic covariances between time series, which makes it a natural fit to this task. Recent advances in scalable approximate inference techniques and the availability of robust open-source libraries have rendered the WP practically viable for fMRI applications. We introduce a comprehensive benchmarking framework to assess WP performance compared with a selection of established TVFC estimation methods. The framework comprises simulations with specified ground-truth covariance structures, a subject phenotype prediction task, a test-retest study, a brain state analysis, an external stimulus prediction task, and a novel data-driven imputation benchmark. The WP performed competitively across all the benchmarks. It outperformed a sliding window (SW) approach with adaptive cross-validated window lengths and a dynamic conditional correlation (DCC)-multivariate generalized autoregressive conditional heteroskedasticity (MGARCH) baseline on the external stimulus prediction task, while being less prone to false positives in the TVFC null models.