Abstract
A genome-wide scan for idiopathic PD in a sample of 113 PD-affected sibling pairs is reported. Suggestive evidence for linkage was found for chromosomes 1 (214 cM, lod = 1.20), 9 (136 cM, lod = 1.30), 10 (88 cM, lod = 1.07), and 16 (114 cM, lod = 0.93). The chromosome 9 region overlaps the genes for dopamine β-hydroxylase and torsion dystonia. Although no strong evidence for linkage was found for any locus, these results may be of value in comparison with similar studies by others.
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CITATION STYLE
DeStefano, A. L., Golbe, L. I., Mark, M. H., Lazzarini, A. M., Maher, N. E., Saint-Hilaire, M., … Myers, R. H. (2001). Genome-wide scan for Parkinson’s disease: The GenePD study. Neurology, 57(6), 1124–1126. https://doi.org/10.1212/WNL.57.6.1124
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