Abstract
A phenalenone compound, atrovenetinone methyl acetal, was isolated from a culture broth of Penicillium sp. FKI-1463 as an HIV-1 integrase inhibitor, and it showed anti-HIV activity in vitro. HIV-1 integrase inhibition and anti-HIV activity of two other natural phenalenones were also studied. Among the tested compounds, funalenone inhibited HIV-1 integrase with an IC50 value of 10 μM and showed the best selectivity (anti-HIV, IC50=1.7 μM; cytotoxicity, IC50=87 μM). © Japan Antibiotics Research Association.
Author supplied keywords
Cite
CITATION STYLE
Shiomi, K., Matsui, R., Isozaki, M., Chiba, H., Sugai, T., Yamaguchi, Y., … Tanaka, H. (2005). Fungal phenalenones inhibit HIV-1 integrase. Journal of Antibiotics, 58(1), 65–68. https://doi.org/10.1038/ja.2005.8
Register to see more suggestions
Mendeley helps you to discover research relevant for your work.
