Solasodine Glycosides: A Topical Therapy for Actinic Keratosis. A Single-Blind, Randomized, Placebo-Controlled, Parallel Group Study with Curaderm BEC5

Abstract

See, stats, and : https : / / www . researchgate . net / publication / 272669666 Solasodine : A Actinic . A - Blind , Randomized , Placebo - Controlled , Parallel . . . Article DOI : 10 . 4236 / jct . 2013 . 42076 CITATIONS 9 READS 48 1 : Some : plasma , a phase Bill The 84 , 456 SEE All . The . ABSTRACT Background : Untreated actinic keratosis can advance to squamous cell carcinoma , which in turn is associated with a risk of metastasis . Current treatments for actinic keratosis have many shortcomings . This communication describes the efficacy and safety of a topical cream therapy , Curaderm BEC5 , containing solasodine glycosides (0 . 005%) for actinic keratosis . Methods : Randomly assigned patients with actinic keratosis on the face , trunk or extremities received so - lasodine glycosides cream (Curaderm BEC5) or placebo (vehicle) that was self - applied to the lesions and covered with an occlusive dressing (micropore) twice daily for 3 consecutive days . Complete clearance and local reactions were as - sessed at 56 days with follow - up periods of 6 months and 1 year . Results : The rate of complete clearance at day 56 was higher with solasodine glycosides than with placebo (92% vs . 38% , P < 0 . 001) . The absolute success rates after 1 year follow - up were 82% for solasodine glycosides and 18% for placebo . No differences in local reactions were obtained when solasodine glycosides and placebo were compared . Local reactions in both groups peaked at days 2 and 3 with local pain as the major event . The pain associated with treatments lasted approximately 10 minutes after application of solasodine glycosides and placebo . Complete reepithelialization occurred two weeks after treatment . Adverse events were generally mild to moderate in intensity and resolved without sequelae . Conclusions : Solasodine glycosides cream applied topically twice daily with a dressing for 3 days is effective for the treatment of actinic keratoses .