Lignans from Bark of the Olea Plants. I

Abstract

Four new lignans, (+)-l-acetoxypinoresinol [(1S,2R,5R,6S)-l-acetoxy-2,6-bis(4-hydroxy-3-methoxyphenyl)-3,7-dioxabicyclo[3.3.0]octane] (1), (+)-l-hydroxypinoresinol (2), (+)-l-acetoxypinoresinol 4 ’-O-methyl ether (3) and (+)-l-hydroxypinoresinol 4 ’-O-methyl ether (4), and two known lignans, (-)-olivil (5) and (+)-cyclo-olivil (6), were isolated from the bark of Olea europaea L. (Oleaceae). Their structures were elucidated on the basis of spectroscopic analysis and chemical evidence. The lignans 1, 2 and 3 were also isolated from the bark of Olea africana Mill. (Olea europaea L. subsp. africana (Mill.) green), And lignans 5 and 6 from the bark of Olea capensis L. © 1984, The Pharmaceutical Society of Japan. All rights reserved.