G0 is a major growth cone protein subject to regulation by GAP-43

Abstract

G0, a GTP-binding protein that transduces information from transmembrane receptors, has been found to be a major component of the neuronal growth cone membrane. GAP-43, an intracellular growth cone protein closely associated with neuronal growth, stimulates GTP-γ-S binding to G0. It does so through an amino-terminal domain homologous to G-linked transmembrane receptors. Thus, G0in the growth cone may be regulated by intracellular as well as extracellular signals. © 1990 Nature Publishing Group.