6315-S (flomoxef) in surgical patients

Abstract

6315-S (flomoxef), a new intravenously injectable oxacephem, was administered to 6 patients with surgical infections and another 4 patients with biliary drainage after laparotomy. The daily dose administered to the 6 surgical patients ranged from 2-4g with a maximal total dose of 39 g over 13 days. In one patient with liver abscess, the drug was administered via celiac axis by Seldinger's method. Clinical response was: excellent in 2, good in 2 and poor in 2 cases. No adverse effects were observed. Early and high concentration levels of 6315-S were observed in bile after i. v. administration of 1g of 6315-S. © 1987, Japanese Society of Chemotherapy. All rights reserved.