Ligand-accelerated site-selective Csp2-H and Csp3-H alkynylations of alcohols: Via Pd(ii) catalysis

Abstract

A ligand-accelerated site-selective C-H alkynylation of weakly coordinated yet synthetically promising alcohols, via putative 6, 7 and 8-membered palladacycle intermediates, was developed. The endo-type C-H activation of olefins has been previously well developed, and in the current work we developed an exo C-H alkynylation of alkenols. Importantly, by making judicious choices of amide attached oximes, challenging secondary and tertiary Csp3-H alkynylations of alcohols were also realized. This journal is