Small molecule-gold nanorod conjugates selectively target and induce macrophage cytotoxicity towards breast cancer cells

Abstract

Gold nanoparticles are known to activate anti-tumor potential in macrophage immune cells; however, the subsequent effects of these cells on others nearby are poorly understood. A novel gold-nanoparticle conjugate that selectively targets and induces cytotoxic activity of tumor-associated macrophages towards breast cancer cells in co-culture is synthesized. These constructs are promising new tools for studying fundamental biological interactions with nanoscale materials and candidates for emerging macrophage-mediated delivery applications. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.