A revised synthesis of the antitumour antibiotic L-azatyrosine via 2-iodo-5-methoxypyridine

Abstract

A revised synthesis of the antitumour antibiotic L-azatyrosine is reported, the main features of which are the unambiguous synthesis of the previously misinterpreted 2-iodo-5-methoxypyridine and subsequent palladium-catalysed coupling with an iodoalanine-derived zinc reagent.