A mild palladium-catalyzed Suzuki coupling reaction of quinoline carboxylates with boronic acids

Abstract

A palladium-catalyzed cross-coupling between aryl carboxylates and boronic acids has been achieved for the first time by taking advantage of the enhanced reactivity of quinoline 4-carboxylates. Also for the first time a Suzuki coupling reaction via a self-activation of boronic acids without addition of base is described. The reactions proceed under mild conditions (25-65°C) to give excellent yields, and a wide range of functionalities is tolerated. Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.