Synthesis of thiazolidin-4-ones from substituted (Ylidene) hydrazinecarbothioamides and dimethyl acetylenedicarboxylate

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Abstract

Conjugated substituted (ylidene)hydrazinecarbothioamides react in high yield with dimethyl acetylenedicarboxylate to give substituted [(ylidene)hydrazono)-4-oxothiazolidin-5-ylidene]acetates; several mechanistic options involving nucleophilic interaction are presented. © 2013 HeteroCorporation.

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Hassan, A. A., Aly, A. A., El-Shaieb, K. M. A., Bedair, T. M. I., Bräse, S., & Brown, A. B. (2014). Synthesis of thiazolidin-4-ones from substituted (Ylidene) hydrazinecarbothioamides and dimethyl acetylenedicarboxylate. Journal of Heterocyclic Chemistry, 51(3), 674–682. https://doi.org/10.1002/jhet.1642

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