Grinding the Cubes-Multigram Solid-State Synthesis of Silsesquioxane Amic Acids

Abstract

For the first time, ball milling is used in the functionalization of silsesquioxanes. The solid-state nucleophilic addition of aminopropylisobutyl POSS to cyclic anhydrides leads to silsesquioxane amic acids in virtually quantitative yields without the use of a solvent. The reactions are easily scalable and can be adopted to multigram quantities.