Abstract
The anti-influenza therapeutic baloxavir targets capdependent endonuclease activity of polymerase acidic (PA) protein. We monitored baloxavir susceptibility in the United States with next generation sequencing analysis supplemented by phenotypic one-cycle infection assay. Analysis of PA sequences of 6,891 influenza A and B viruses collected during 2016/17 and 2017/18 seasons showed amino acid substitutions: I38L (two A(H1N1)pdm09 viruses), E23G (two A(H1N1) pdm09 viruses) and I38M (one A(H3N2) virus); conferring 4–10-fold reduced susceptibility to baloxaviryears.
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CITATION STYLE
Gubareva, L. V., Mishin, V. P., Patel, M. C., Chesnokov, A., Nguyen, H. T., De La Cruz, J., … Wentworth, D. E. (2019). Assessing baloxavir susceptibility of influenza viruses circulating in the United States during the 2016/17 and 2017/18 seasons. Eurosurveillance, 24(3). https://doi.org/10.2807/1560-7917.ES.2019.24.3.1800666
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