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Subcellular localization of anthracyclines in cultured rat cardiomyoblasts as possible predictors of cardiotoxicity

Investigational New Drugs (2015) 33(5) 1032-1039
DOI: 10.1007/s10637-015-0276-9
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Abstract

Summary: In this study, we compared the cellular uptake, intracellular localization and cytotoxicity of two groups of anthracycline derivatives in cultured H9c2(2-1) rat cardiomyoblasts. The first group consisted of doxorubicin (DOX) and two of its derivatives containing a formamidino group (-N∈=∈CH-N

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Studzian, K., Kik, K., Lukawska, M., Oszczapowicz, I., Strek, M., & Szmigiero, L. (2015). Subcellular localization of anthracyclines in cultured rat cardiomyoblasts as possible predictors of cardiotoxicity. Investigational New Drugs, 33(5), 1032–1039. https://doi.org/10.1007/s10637-015-0276-9

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