Effect of randomly interesterified triacylglycerol containing mediumand long-chain fatty acids on hepatic fatty acid oxidation after a single administration to rats

Abstract

MLCTs, which are randomly interesterified triacylglycerol containing medium-and long-chain fatty acids in the same glycerol molecule, showed significantly higher acyl-CoA dehydrogenase activity when measured by using butyryl-CoA, octanoyl-CoA, and palmitoyl-CoA as substrates than long-chain triacylglycerol one hour after a single administration to rats. These results suggest that not only medium-chain fatty acid oxidation, but also long-chain fatty acid oxidation were increased in the liver of rats administered with MLCT.