Molecular approach to skin aging: new perspectives

Abstract

Introduction: skin aging is a physiological process that causes concern in people by modifying the morphological characteristics of the skin; Beyond aesthetics, the skin is an organ with various functions, such as protection, hormone secretion, temperature regulation; Aging can be of two types: intrinsic, produced by the senescence of cells, extrinsic: produced by the interaction of all the components of the skin and external factors, the best known being ultraviolet (UV) rays from the sun. Objectives: a bibliographic review of the histophysiology of the skin and its aging was carried out, to describe updated scientific evidence on the etiopathogenesis and treatment of skin aging. Methods: this bibliographic review was carried out through a literature search through databases such as: Pubmed, NIH/PMC, Springer, Google Scholar; that have been published in the period 2019 to 2023. Conclusions: skin aging is a process that we will all suffer from, however, exposure to external factors such as UV rays accelerate it by increasing the secretory pattern which in turn increases the presence of metalloproteinases. There are no key studies that demonstrate the effectiveness of any treatment that completely stops this process.